目的 探讨甲状腺恶性结节与代谢综合征相关组分及尿碘的相关性。方法 回顾性分析2012年8月-2016年5月在本院因甲状腺结节行甲状腺细针穿刺活组织检查（fine needle aspiration biopsy, FNAB）的完整病例资料245例，分为恶性和非恶性结节组。专人测身高、体重、血压、空腹血糖、血脂、尿碘及甲状腺功能相关指标，并进行统计学分析。结果 （1）FNAB诊断甲状腺恶性结节54例，非恶性结节191例。恶性结节组体重指数(body mass index, BMI)（25.53±2.90 vs 22.90±2.58 ）、空腹血糖(fasting blood glucose, FBG)（6.68±1.529 vs 5.69±1.58）、甘油三酯(serum glycerin trilaurate, TG)（1.68±1.13 vs 1.32±1.05）、促甲状腺激素(serum thyroid stimulating hormone, TSH)（3.77±2.15 vs 2.47±3.03）及尿碘（335.6±207.3 vs 194.1±182.4）均显著高于非恶性结节组（均P<0.05）。（2）多因素Logistic回归分析显示，甲状腺恶性结节与年龄、BMI、FBG、尿碘含量独立相关，与TSH及TG无明显相关。结论 代谢综合症相关组分和尿碘含量与甲状腺恶性结节密切相关。
Abstract
Objective To explore the correlation of malignant thyroid nodules with metabolic syndrome components and urinary iodine. Methods A retrospective analysis was used to analyze 245 patients who were diagnosed with thyroid nodules and then received thyroid fine needle aspiration biopsy (FNAB) in our hospital during 2012.8-2016.5, according to the FNAB results, the cases were divided into benign and malignant thyroid nodules groups. A certain technician measured height, weight, blood pressure, fasting blood glucose, serum lipid profile, urinary iodine and serum thyroid function index, at the same time, analysed data by statistical methods. Results (1) There were 54 cases of malignant thyroid nodules and 191 cases of benign thyroid nodules. Compared with benign thyroid nodules group, the malignant thyroid nodules group showed higher levels of body mass index (BMI) (25.53±2.90 vs. 22.90±2.58), fasting blood glucose (FBG)（6.68±1.529 vs. 5.69±1.58）, serum glycerin trilaurate (TG)（1.68±1.13 vs. 1.32±1.05）, serum thyroid stimulating hormone (TSH)（3.77±2.15 vs. 2.47±3.03） and urinary iodine（335.6±207.3 vs. 194.1±182.4） ( each P<0.05). (2) In multivariate Logistic regression analysis, factors which were independently correlated with malignant thyroid nodule formation were age, BMI, FBG and urinary iodine, but not TG and TSH. Conclusions metabolic syndrome components and urinary iodine are profoundly related to maligant thyroid nodules.
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参考文献
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